- Title
- Long-term event-related potential changes following organophosphorus insecticide poisoning
- Creator
- Dassanayake, T.; Weerasinghe, V.; Dangahadeniya, U.; Kularatne, K.; Dawson, A.; Karalliedde, L.; Senanayake, N.
- Relation
- Clinical Neurophysiology Vol. 119, Issue 1, p. 144-150
- Publisher Link
- http://dx.doi.org/10.1016/j.clinph.2007.09.134
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2008
- Description
- Objective: To determine prolonged effects of organophosphorus (OP) insecticide poisoning on cognitive event-related potentials (ERPs). Methods: ERPs of a group of 32 patients recovered from cholinergic phase of OP insecticide poisoning were compared with those of two matched control groups: 32 healthy volunteers and nine patients hospitalised with paracetamol overdose. A follow-up assessment was done in 21 patients (66% of the initial sample) 6 months after OP intoxication and the findings were compared with their initial ERP data. Results: Patients showed highly significant prolongation of P300 latency, compared to healthy controls (p = 0.003) and the controls with paracetamol overdose (p = 0.016). Follow-up ERP findings of the patients revealed that this impairment remained unchanged even 6 months after OP poisoning (p = 0.790). There was no significant difference in N100, P200 and N200 latencies or P300 amplitude either among the groups or between the two assessments of the patients with OP poisoning. Conclusions: Our results suggest that acute OP poisoning causes a delay in cognitive processes involved in stimulus classification, lasting at least for 6 months. Significance: These findings highlight the possibility of development of long-lasting cognitive deficits following OP insecticide poisoning, and warrant longer-term prospective studies to determine whether this impairment is permanent.
- Subject
- organophosphorus insecticide poisoning; Cognitive effects; P300; event-related potentials
- Identifier
- http://hdl.handle.net/1959.13/41404
- Identifier
- uon:4771
- Identifier
- ISSN:1388-2457
- Language
- eng
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